Recently at a retreat I made a small Uneven Nine Patch, so this would be a good time to post this block. It's made with small blocks, but it would look good in a larger size, too.
Typically, the Uneven Nine-Patch is made with the center square twice as large as the corner squares. So, to make a 12" finished block, you'll need:
(1) 6-1/2" square dark
(4) 3-12" squares dark
(4) 3-1/2" x 6-1/2" rectangles light
Arrange them as you would a 5 dark/4 light nine patch:
You could also double-up on this block, replacing the larger square in the center with a pieced block.
Or, perhaps a large print in the center, and coordinating solid-ish fabrics in the corners.
Or, use it as a signature block, with people signing in the light rectangles. (Hmmm...maybe with photos as the center piece?)